发现
一项研究 由 皇冠hga025大学洛杉矶分校健康 Jonsson Comprehensive 癌症中心 researchers found that using a combination of experimental immunotherapy drugs with 化疗 significantly improves progression-free survival and overall survival for patients with metastatic colorectal cancer who have previously undergone standard 化疗 treatment when compared to those who received the targeted therapy regorafenib alone.
The median progression-free survival, which is the amount of time during and after treatment when the cancer does not worsen or progress, with the combination treatment was 6.2 months compared to 2.1 months for those in the targeted therapy only group.
The median overall survival with the combination treatment was 19.7 months as compared to 9.5 months for those in the targeted therapy only group.
The results of the study also showed treatment with the novel combination therapy either partially or completely shrank tumors in 17.3%的患者. For patients on regorafenib only, 2.7% had tumor shrinkage.
BACKGROUND
When colorectal cancer starts to spread to other parts of the body, it can be more challenging to treat and often requires a combination of therapies, 包括手术, 化疗, targeted therapies and immunotherapy. While these advancements in treatment options have improved outcomes for many patients with metastatic colorectal cancer, it still remains a significant health issue. Conventional treatments often become ineffective as the disease progresses, requiring the development of innovative therapeutic approaches.
方法
This group of investigators looked at evaluating the efficacy of a novel treatment combination, 叫EZFB, which consists of etrumadenant (E), a dual A2a/A2b adenosine receptor antagonist, zimberelimab (Z), an immune checkpoint inhibitor, and a 化疗 regimen (FB: mFOLFOX-6 ± bevacizumab), to see if it could improve outcomes for people who were previously treated for this aggressive form of cancer.
The team enrolled 112 participants with metastatic colorectal cancer who had previously undergone treatment with oxaliplatin and irinotecan-containing regimens in the Phase Ib/II trial. The patients were randomized into two groups: 75 receiving the EZFB combination and 37 receiving regorafenib alone.
影响
The study's findings underscore the potential of combining immune-targeted therapy with traditional 化疗 to better control the spread of the cancer and enhance the effectiveness of the treatment in metastatic colorectal cancer.
"The improvement in both progression-free survival and overall survival observed with the EZFB combination represents a significant advancement in the management of refractory metastatic colorectal cancer,” said first author of the abstract Dr. 泽夫·温伯格, co-director of the 皇冠hga025大学洛杉矶分校健康 GI Oncology Program and researcher at the 皇冠hga025大学洛杉矶分校健康 Jonsson Comprehensive 癌症中心. “These results pave the way for further exploration of this promising treatment approach."
作者
The abstract’s senior author is Michael Cecchini from Yale University 医学院. Other authors are Sae-Won Han, Soohyeon李, Keun-Wook李, 斯科特Kopetz, 乔纳森Mizrahi, 永生洪, 弗朗索瓦Ghiringhelli, 安东尼意大利语, 大卫Tougeron, 布兰登小猎犬, 马修Boakye, 婷婷赵, Joon Rhee and Dimitry Nuyten.
会话
Wainberg will present the findings (摘要3508年) at the annual American Society of Clinical Oncology meeting on Sunday, June 2 during the 口头摘要会议 of the Gastrointestinal 癌症—Colorectal and Anal Track from 8 to 11am CT.
The study was sponsored by Arcus Biosciences.
